Pharmacologic Receptor Activity of Rabbit Aorta

Pharmacologic receptor activity of rabbit aorta. Effect of dithiothreitol and N-ethylmaleimide.

IV-ethylmaleimide (NEM), an alkylating agent that covalently binds sulfhydryl groups, and dithiothreitol (DTT, Cleland's reagent), which reduces disulfide bridges to sulfhydryl groups, affected drug-induced contractions of rabbit aorta. NEM depressed aortic responses to potassium chloride (KC1), norepinephrine, serotonin, histamine, and angiotensin II. This action was attributed to an interacti...

Rabbit Aorta

We previously showed by qualitative en face autoradiography that after 24 hours of circulation, I-labeled low density lipoprotein (LDL) injected in tracer amounts accumulated focally at the edges of regenerating endothelial islands in the balloon catheter-deendothelialized aorta of the normocholesterolemic rabbit In the present study with the same animal model, we have used quantitative autorad...

Rhythmic electrical activity in rabbit aorta induced by EGTA.

Endothelium-Dependent Relaxation of Rabbit Aorta

Exposure of isolated arteries to oxidatively modified low density lipoprotein (LDL) has been reported to suppress endothelium-dependent relaxation (EDR). To determine whether lipid degradation products in oxidized LDL contribute to impaired relaxation, we have tested the responsiveness of isolated rabbit aortas to endothelium-dependent relaxants (acetylcholine, ATP, and calcium ionophore A23187...

Haemodynamic Study of the Rabbit Aorta

INTRODUCTION Atherosclerosis is characterised by the accumulation of lipids within the arterial wall. The disease preferentially targets curved arteries and branching regions and the lesion distribution has been observed to change with age in both humans and rabbits [1]. These age-related differences may be a consequence of changes in the flow characteristics. In order to investigate this hypot...